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In this issue
December 2, 2014

Jonathan Tobin: Defending the Right to a Jewish State

Heather Hale: Compliment your kids without giving them big heads

Megan Shauri: 10 ways you are ruining your own happiness

Carolyn Bigda: 8 Best Dividend Stocks for 2015

Kiplinger's Personal Finance editors: 7 Things You Didn't Know About Paying Off Student Loans

Samantha Olson: The Crucial Mistake 55% Of Parents Are Making At Their Baby's Bedtime

Densie Well, Ph.D., R.D. Open your eyes to yellow vegetables

The Kosher Gourmet by Megan Gordon With its colorful cache of purples and oranges and reds, COLLARD GREEN SLAW is a marvelous mood booster --- not to mention just downright delish
April 18, 2014

Rabbi Yonason Goldson: Clarifying one of the greatest philosophical conundrums in theology

Caroline B. Glick: The disappearance of US will

Megan Wallgren: 10 things I've learned from my teenagers

Lizette Borreli: Green Tea Boosts Brain Power, May Help Treat Dementia

John Ericson: Trying hard to be 'positive' but never succeeding? Blame Your Brain

The Kosher Gourmet by Julie Rothman Almondy, flourless torta del re (Italian king's cake), has royal roots, is simple to make, . . . but devour it because it's simply delicious

April 14, 2014

Rabbi Dr Naftali Brawer: Passover frees us from the tyranny of time

Greg Crosby: Passing Over Religion

Eric Schulzke: First degree: How America really recovered from a murder epidemic

Georgia Lee: When love is not enough: Teaching your kids about the realities of adult relationships

Cameron Huddleston: Freebies for Your Lawn and Garden

Gordon Pape: How you can tell if your financial adviser is setting you up for potential ruin

Dana Dovey: Up to 500,000 people die each year from hepatitis C-related liver disease. New Treatment Has Over 90% Success Rate

Justin Caba: Eating Watermelon Can Help Control High Blood Pressure

The Kosher Gourmet by Joshua E. London and Lou Marmon Don't dare pass over these Pesach picks for Manischewitz!

April 11, 2014

Rabbi Hillel Goldberg: Silence is much more than golden

Caroline B. Glick: Forgetting freedom at Passover

Susan Swann: How to value a child for who he is, not just what he does

Cameron Huddleston: 7 Financial Tasks You Should Tackle Right Now

Sandra Block and Lisa Gerstner: How to Profit From Your Passion

Susan Scutti: A Simple Blood Test Might Soon Diagnose Cancer

Chris Weller: Have A Slow Metabolism? Let Science Speed It Up For You

The Kosher Gourmet by Diane Rossen Worthington Whitefish Terrine: A French take on gefilte fish

April 9, 2014

Jonathan Tobin: Why Did Kerry Lie About Israeli Blame?

Samuel G. Freedman: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Jessica Ivins: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Kim Giles: Asking for help is not weakness

Kathy Kristof and Barbara Hoch Marcus: 7 Great Growth Israeli Stocks

Matthew Mientka: How Beans, Peas, And Chickpeas Cleanse Bad Cholesterol and Lowers Risk of Heart Disease

Sabrina Bachai: 5 At-Home Treatments For Headaches

The Kosher Gourmet by Daniel Neman Have yourself a matzo ball: The secrets bubby never told you and recipes she could have never imagined

April 8, 2014

Lori Nawyn: At Your Wit's End and Back: Finding Peace

Susan B. Garland and Rachel L. Sheedy: Strategies Married Couples Can Use to Boost Benefits

David Muhlbaum: Smart Tax Deductions Non-Itemizers Can Claim

Jill Weisenberger, M.S., R.D.N., C.D.E : Before You Lose Your Mental Edge

Dana Dovey: Coffee Drinkers Rejoice! Your Cup Of Joe Can Prevent Death From Liver Disease

Chris Weller: Electric 'Thinking Cap' Puts Your Brain Power Into High Gear

The Kosher Gourmet by Marlene Parrish A gift of hazelnuts keeps giving --- for a variety of nutty recipes: Entree, side, soup, dessert

April 4, 2014

Rabbi David Gutterman: The Word for Nothing Means Everything

Charles Krauthammer: Kerry's folly, Chapter 3

Amy Peterson: A life of love: How to build lasting relationships with your children

John Ericson: Older Women: Save Your Heart, Prevent Stroke Don't Drink Diet

John Ericson: Why 50 million Americans will still have spring allergies after taking meds

Cameron Huddleston: Best and Worst Buys of April 2014

Stacy Rapacon: Great Mutual Funds for Young Investors

Sarah Boesveld: Teacher keeps promise to mail thousands of former students letters written by their past selves

The Kosher Gourmet by Sharon Thompson Anyone can make a salad, you say. But can they make a great salad? (SECRETS, TESTED TECHNIQUES + 4 RECIPES, INCLUDING DRESSINGS)

April 2, 2014

Paul Greenberg: Death and joy in the spring

Dan Barry: Should South Carolina Jews be forced to maintain this chimney built by Germans serving the Nazis?

Mayra Bitsko: Save me! An alien took over my child's personality

Frank Clayton: Get happy: 20 scientifically proven happiness activities

Susan Scutti: It's Genetic! Obesity and the 'Carb Breakdown' Gene

Lecia Bushak: Why Hand Sanitizer May Actually Harm Your Health

Stacy Rapacon: Great Funds You Can Own for $500 or Less

Cameron Huddleston: 7 Ways to Save on Home Decor

The Kosher Gourmet by Steve Petusevsky Exploring ingredients as edible-stuffed containers (TWO RECIPES + TIPS & TECHINQUES)

Jewish World Review

T cell modification curbs girl's leukemia

By Heather Hottle





Doctors and researchers are using what they learned to treat other cancer patients who have run out of conventional options


JewishWorldReview.com |

RTATE COLLEGE, Pa. — (MCT) A 7-year-old Pennsylvania girl, after a two-year battle with acute lymphoblastic leukemia, became the first child to receive an experimental treatment that used a genetically modified version of her own immune system to fight it off.

Emily "Emma" Whitehead and her parents, Tom and Kari Whitehead of Philipsburg, Pa., turned to experts at the University of Pennsylvania and the Children's Hospital of Philadelphia for help when chemotherapy failed and she could not remain in remission long enough to receive a bone-marrow transplant.

In April, Emily became the first child have her own T cells — infection-fighting white blood cells in her immune system — genetically engineered to recognize and attack the cancer cells in her body. The doctors removed her T cells through a process similar to blood donation, programmed them to attack her cancer, then grew them and injected them back into her body.

Two months later, tests on Emily had found no cancer and she got to go home.


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Since then, the doctors and researchers have been using what they learned from Emily's case to treat other cancer patients who have run out of conventional options. They described their work over the weekend at the American Society of Hematology's annual meeting in Atlanta.

Their aim is to eventually replace bone-marrow treatments with the new T cell therapy.

"We are basically trying to treat cancer a whole new way," said Dr. Stephen Grupp, the pediatric oncologist who treated Emily at the Philadelphia hospital.

T cells are "immune cells in the body that are actually very good at getting rid of cells that don't belong," Grupp said, but "unfortunately, cancer is really good at dodging T cells."

Researchers have been working for years to develop a way to "train" these cells to multiply and attack cancer, similar to a vaccine.

But "all those efforts have been essentially unsuccessful because once you get a big tumor in your body, it's very hard to marshal up the immune system," said Michael Kalos, director of the Translational and Correlative Studies Laboratory in Penn's Perelman School of Medicine.

So researchers decided to attempt to grow the T cells outside the body so there would be plenty to fight off a tumor. This process is known as adoptive T cell transfer, or adoptive immunotherapy.

"So instead of trying to stimulate or trigger a rare cell in somebody's body by a vaccine, you give them the end product of that, which is a billion cells that are engineered to recognize what you want them to recognize," Kalos said.

Emily's form of cancer is leukemia of the B cells, which are another type of white blood cell.

Researchers are "putting in a new gene using a virus. That gene gets incorporated into the actual DNA of the cell and that gene produces a new protein that doesn't exist in nature," Grupp said.

The two innovations that make the treatment possible are creating the new protein, and then getting it onto the T cell 's surface.

That protein is called a chimeric antigen receptor, or CAR, and it forces a T cell to go after and bind with a target on a cancer cell.

In Emily's case, that target is another protein, called CD 19, which is only present on the surface of B cells.

"You could call that the 'guided missile rationale,'" said Bruce Levine, director of the Clinical Cell and Vaccine Production Facility, because the T cells only kill the B cells. That is different from traditional chemotherapy, which doesn't have a specific target.

The research team used a gutted HIV virus, called a lentivirus, to introduce the chimeric antigen receptors into the T cells. The infectious part of the virus is removed, leaving "just the carcass" behind for this process, so there is no risk of viral infection, Kalos said.

Once the T cells are grown and testing is complete, a process that takes at least three weeks, they are given back to the patients to start fighting the disease.

The idea is similar to that of an immunization. The difference is that with immunizations, the T cells learn how to attack a disease by themselves.

"We're not letting the immune system figure it out by itself," Grupp said. "We're forcing it to attack by using this genetic engineering approach."

Grupp said the advantage to using T cells instead of traditional cancer treatments is that successfully introduced T cells grow in the body and will potentially be there for a long time to keep looking for cancer cells.

Penn researchers first reported on this type of successful T cell treatment last year. Three adults were treated and two had complete remission. Their cases were detailed in the New England Journal of Medicine and Science Translational Medicine in August 2011.

Two years after treatment, the two adults still have no evidence of disease — they also still have the engineered T cells in their bodies, a major scientific breakthrough, researchers said.

"The problem is that lots of people have figured out how to engineer T cells, lots of people figured out how to grow T cells in a lab, but nobody figured out how to make the cells actually grow in the patient," Grupp said.

That is, until now.

This weekend, researchers shared new data showing that nine of 12 patients with advanced leukemia in the clinical trial, including Emily and another child after her, responded to treatment.

"When we first treated our first three adults ... the results came back over a period of six weeks, and at that point I knew that my life was forever changed," said June, director of translational research in Penn's Abramson Cancer Center.

"We were worried that there was a small number of patients but what we've seen has never been seen before. And now ... two years later, the results have held up and we have more patients. ... I was always worried that this is a fluke of small numbers ... but now we know that is wasn't just a fluke. In April, when Emily got treated, it both confirmed it and then showed that it works in a different kind of cancer."

June hopes that genetically engineered T cells will one day replace more invasive procedures such as bone-marrow transplants.

The Penn research team is working to expand the study soon with more pediatric and adult patients.

While Emily has stayed in remission for more than six months, a second child had not been able to sustain remission.

"Our goal is to treat another dozen patients in the next nine to 12 months," Grupp said. "We're very excited about the results. Clearly we need more experience with this to see how we do in a broader group."

The team is also looking to expand the T cell study to different types of leukemia over the next year and to other types of cancers.

While Emily was being treated, the Whiteheads updated family and friends on her progress through a Facebook page.

Today, that page has more than 17,600 followers, and her celebrity is expected to grow.

"It seems like everywhere we go someone recognizes Emily," Tom Whitehead said.

But they're just taking it in stride. Their goal is to let everyone possible — especially other families with children facing cancer — about the T cell study.

"We're really trying to do as much as we can," he said. "Parents whose kids are having leukemia relapses and they don't know what to do need to know about it."

Grupp and the rest of the team at CHOP and Penn will continue to monitor Emily's progress with testing and a bone-marrow check every three months. She's had a few complications, such as a bout of salmonella, but she's back in school and excelling.

While the T cells have gone down in number since they're not actively fighting cancer cells, they still remain present in her body, just like the adults who underwent successful treatment before her.

"We do not use the C-word. We cannot say that (Emily) is cured for a long, long time, but things are looking very good so far," Kalos said. "We still see T cells in her blood. We still see no evidence of disease. All green lights for (Emily) so far."

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