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In this issue

Jonathan Tobin: Defending the Right to a Jewish State

Heather Hale: Compliment your kids without giving them big heads

Megan Shauri: 10 ways you are ruining your own happiness

Carolyn Bigda: 8 Best Dividend Stocks for 2015

Kiplinger's Personal Finance editors: 7 Things You Didn't Know About Paying Off Student Loans

Samantha Olson: The Crucial Mistake 55% Of Parents Are Making At Their Baby's Bedtime

Densie Well, Ph.D., R.D. Open your eyes to yellow vegetables

The Kosher Gourmet by Megan Gordon With its colorful cache of purples and oranges and reds, COLLARD GREEN SLAW is a marvelous mood booster --- not to mention just downright delish
April 18, 2014

Rabbi Yonason Goldson: Clarifying one of the greatest philosophical conundrums in theology

Caroline B. Glick: The disappearance of US will

Megan Wallgren: 10 things I've learned from my teenagers

Lizette Borreli: Green Tea Boosts Brain Power, May Help Treat Dementia

John Ericson: Trying hard to be 'positive' but never succeeding? Blame Your Brain

The Kosher Gourmet by Julie Rothman Almondy, flourless torta del re (Italian king's cake), has royal roots, is simple to make, . . . but devour it because it's simply delicious

April 14, 2014

Rabbi Dr Naftali Brawer: Passover frees us from the tyranny of time

Greg Crosby: Passing Over Religion

Eric Schulzke: First degree: How America really recovered from a murder epidemic

Georgia Lee: When love is not enough: Teaching your kids about the realities of adult relationships

Cameron Huddleston: Freebies for Your Lawn and Garden

Gordon Pape: How you can tell if your financial adviser is setting you up for potential ruin

Dana Dovey: Up to 500,000 people die each year from hepatitis C-related liver disease. New Treatment Has Over 90% Success Rate

Justin Caba: Eating Watermelon Can Help Control High Blood Pressure

The Kosher Gourmet by Joshua E. London and Lou Marmon Don't dare pass over these Pesach picks for Manischewitz!

April 11, 2014

Rabbi Hillel Goldberg: Silence is much more than golden

Caroline B. Glick: Forgetting freedom at Passover

Susan Swann: How to value a child for who he is, not just what he does

Cameron Huddleston: 7 Financial Tasks You Should Tackle Right Now

Sandra Block and Lisa Gerstner: How to Profit From Your Passion

Susan Scutti: A Simple Blood Test Might Soon Diagnose Cancer

Chris Weller: Have A Slow Metabolism? Let Science Speed It Up For You

The Kosher Gourmet by Diane Rossen Worthington Whitefish Terrine: A French take on gefilte fish

April 9, 2014

Jonathan Tobin: Why Did Kerry Lie About Israeli Blame?

Samuel G. Freedman: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Jessica Ivins: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Kim Giles: Asking for help is not weakness

Kathy Kristof and Barbara Hoch Marcus: 7 Great Growth Israeli Stocks

Matthew Mientka: How Beans, Peas, And Chickpeas Cleanse Bad Cholesterol and Lowers Risk of Heart Disease

Sabrina Bachai: 5 At-Home Treatments For Headaches

The Kosher Gourmet by Daniel Neman Have yourself a matzo ball: The secrets bubby never told you and recipes she could have never imagined

April 8, 2014

Lori Nawyn: At Your Wit's End and Back: Finding Peace

Susan B. Garland and Rachel L. Sheedy: Strategies Married Couples Can Use to Boost Benefits

David Muhlbaum: Smart Tax Deductions Non-Itemizers Can Claim

Jill Weisenberger, M.S., R.D.N., C.D.E : Before You Lose Your Mental Edge

Dana Dovey: Coffee Drinkers Rejoice! Your Cup Of Joe Can Prevent Death From Liver Disease

Chris Weller: Electric 'Thinking Cap' Puts Your Brain Power Into High Gear

The Kosher Gourmet by Marlene Parrish A gift of hazelnuts keeps giving --- for a variety of nutty recipes: Entree, side, soup, dessert

April 4, 2014

Rabbi David Gutterman: The Word for Nothing Means Everything

Charles Krauthammer: Kerry's folly, Chapter 3

Amy Peterson: A life of love: How to build lasting relationships with your children

John Ericson: Older Women: Save Your Heart, Prevent Stroke Don't Drink Diet

John Ericson: Why 50 million Americans will still have spring allergies after taking meds

Cameron Huddleston: Best and Worst Buys of April 2014

Stacy Rapacon: Great Mutual Funds for Young Investors

Sarah Boesveld: Teacher keeps promise to mail thousands of former students letters written by their past selves

The Kosher Gourmet by Sharon Thompson Anyone can make a salad, you say. But can they make a great salad? (SECRETS, TESTED TECHNIQUES + 4 RECIPES, INCLUDING DRESSINGS)

April 2, 2014

Paul Greenberg: Death and joy in the spring

Dan Barry: Should South Carolina Jews be forced to maintain this chimney built by Germans serving the Nazis?

Mayra Bitsko: Save me! An alien took over my child's personality

Frank Clayton: Get happy: 20 scientifically proven happiness activities

Susan Scutti: It's Genetic! Obesity and the 'Carb Breakdown' Gene

Lecia Bushak: Why Hand Sanitizer May Actually Harm Your Health

Stacy Rapacon: Great Funds You Can Own for $500 or Less

Cameron Huddleston: 7 Ways to Save on Home Decor

The Kosher Gourmet by Steve Petusevsky Exploring ingredients as edible-stuffed containers (TWO RECIPES + TIPS & TECHINQUES)

Jewish World Review

Researchers discover areas in human genome that may help find causes of certain disorders

By Thomas H. Maugh II




http://www.JewishWorldReview.com | (MCT) Researchers have found more than 15 million places in the human genome where the genetic code differs from person to person, providing a catalog of hotspots for genetic change that should speed the search for genetic causes of such complex disorders as diabetes, Alzheimer's and heart disease.

Only 10 years after scientists laboriously unraveled the first sequence of a human genome, an international team said Wednesday they have sequenced the bulk of the genomes from more than 800 people in the pilot stage of the so-called 1000 Genomes Project that aims to complete 2,500 sequences by the end of 2012 at a cost of $120 million.

More than 99 percent of the human genome is identical in all of the Earth's nearly 7 billion inhabitants; it is in that minuscule 1 percent left over that individual physical characteristics, such as eye color, height, and disease propensity lie hidden. The research team reported that it has now identified 95 percent of the individual places in the genome where such information is stored and is well on their way to discovering all of them.

The key to this progress is the development of powerful new DNA-sequencing machines that enable researchers to accomplish in hours feats that used to require months or even years at a fraction of the cost.

"In the last 10 years, DNA sequencing technology has advanced dramatically so that it becomes feasible to systematically sequence many people to find genetic variants and build a catalog which we can use as a basis for investigations into disease genetics and which variants may be functional," Dr. Richard Durbin of the Wellcome Trust Sanger Institute in England, co-chair of the project, said at a news conference.

The human genetic blueprint, or genome, is composed of an estimated 20,000 to 25,000 genes encoded in a chain of about 3.1 billion individual chemicals called bases. The initial effort to decode, or sequence, the genome of one individual took more than 10 years and cost more than $3 billion.

But researchers reported Wednesday in the journal Nature that their pilot project now includes the entire genomes of 179 people of European, West African and East Asian ancestry as well as the gene-coding regions of another 697 people. The resulting information on more than 4.5 trillion bases of DNA sequences is enough to fill 400,000 books the size of the New York City telephone directory.

The results so far have produced a number of surprises.

Among the individuals whose genomes were fully sequenced were two families of father, mother and daughter. The team found that each daughter had about 60 genetic variants that were not inherited from either parent and apparently arose on their own.

The team also discovered that, on average, each person carries between 250 and 300 genetic changes that would cause a gene to stop working normally, and about 50 to 100 genetic variations that have already been associated with an inherited disease. No person carries a perfect set of genes — the fact that everyone has two copies of each gene prevents most of those variations from being problems.

The complete list of genetic variants will give researchers powerful new tools not only for discovering the genetic roots of diseases but for identifying mutations in tumors and other disorders such as heart disease that will respond to specific drugs, theoretically opening a new era of targeted treatments, the researchers said.

In a separate study released online Wednesday by the journal Science, geneticist Evan Eichler of the University of Washington and his colleagues reported that they had found a way to identify multiple copies of genes, a feat which is not achievable by conventional sequencing.

They found that the presence of multiple copies of some genes may be associated with an increased tendency to develop certain diseases. The accumulation of extra copies of genes associated with brain development may have helped humans evolved from lower primates, they found.

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