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December 2, 2014

Jonathan Tobin: Defending the Right to a Jewish State

Heather Hale: Compliment your kids without giving them big heads

Megan Shauri: 10 ways you are ruining your own happiness

Carolyn Bigda: 8 Best Dividend Stocks for 2015

Kiplinger's Personal Finance editors: 7 Things You Didn't Know About Paying Off Student Loans

Samantha Olson: The Crucial Mistake 55% Of Parents Are Making At Their Baby's Bedtime

Densie Well, Ph.D., R.D. Open your eyes to yellow vegetables

The Kosher Gourmet by Megan Gordon With its colorful cache of purples and oranges and reds, COLLARD GREEN SLAW is a marvelous mood booster --- not to mention just downright delish
April 18, 2014

Rabbi Yonason Goldson: Clarifying one of the greatest philosophical conundrums in theology

Caroline B. Glick: The disappearance of US will

Megan Wallgren: 10 things I've learned from my teenagers

Lizette Borreli: Green Tea Boosts Brain Power, May Help Treat Dementia

John Ericson: Trying hard to be 'positive' but never succeeding? Blame Your Brain

The Kosher Gourmet by Julie Rothman Almondy, flourless torta del re (Italian king's cake), has royal roots, is simple to make, . . . but devour it because it's simply delicious

April 14, 2014

Rabbi Dr Naftali Brawer: Passover frees us from the tyranny of time

Greg Crosby: Passing Over Religion

Eric Schulzke: First degree: How America really recovered from a murder epidemic

Georgia Lee: When love is not enough: Teaching your kids about the realities of adult relationships

Cameron Huddleston: Freebies for Your Lawn and Garden

Gordon Pape: How you can tell if your financial adviser is setting you up for potential ruin

Dana Dovey: Up to 500,000 people die each year from hepatitis C-related liver disease. New Treatment Has Over 90% Success Rate

Justin Caba: Eating Watermelon Can Help Control High Blood Pressure

The Kosher Gourmet by Joshua E. London and Lou Marmon Don't dare pass over these Pesach picks for Manischewitz!

April 11, 2014

Rabbi Hillel Goldberg: Silence is much more than golden

Caroline B. Glick: Forgetting freedom at Passover

Susan Swann: How to value a child for who he is, not just what he does

Cameron Huddleston: 7 Financial Tasks You Should Tackle Right Now

Sandra Block and Lisa Gerstner: How to Profit From Your Passion

Susan Scutti: A Simple Blood Test Might Soon Diagnose Cancer

Chris Weller: Have A Slow Metabolism? Let Science Speed It Up For You

The Kosher Gourmet by Diane Rossen Worthington Whitefish Terrine: A French take on gefilte fish

April 9, 2014

Jonathan Tobin: Why Did Kerry Lie About Israeli Blame?

Samuel G. Freedman: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Jessica Ivins: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Kim Giles: Asking for help is not weakness

Kathy Kristof and Barbara Hoch Marcus: 7 Great Growth Israeli Stocks

Matthew Mientka: How Beans, Peas, And Chickpeas Cleanse Bad Cholesterol and Lowers Risk of Heart Disease

Sabrina Bachai: 5 At-Home Treatments For Headaches

The Kosher Gourmet by Daniel Neman Have yourself a matzo ball: The secrets bubby never told you and recipes she could have never imagined

April 8, 2014

Lori Nawyn: At Your Wit's End and Back: Finding Peace

Susan B. Garland and Rachel L. Sheedy: Strategies Married Couples Can Use to Boost Benefits

David Muhlbaum: Smart Tax Deductions Non-Itemizers Can Claim

Jill Weisenberger, M.S., R.D.N., C.D.E : Before You Lose Your Mental Edge

Dana Dovey: Coffee Drinkers Rejoice! Your Cup Of Joe Can Prevent Death From Liver Disease

Chris Weller: Electric 'Thinking Cap' Puts Your Brain Power Into High Gear

The Kosher Gourmet by Marlene Parrish A gift of hazelnuts keeps giving --- for a variety of nutty recipes: Entree, side, soup, dessert

April 4, 2014

Rabbi David Gutterman: The Word for Nothing Means Everything

Charles Krauthammer: Kerry's folly, Chapter 3

Amy Peterson: A life of love: How to build lasting relationships with your children

John Ericson: Older Women: Save Your Heart, Prevent Stroke Don't Drink Diet

John Ericson: Why 50 million Americans will still have spring allergies after taking meds

Cameron Huddleston: Best and Worst Buys of April 2014

Stacy Rapacon: Great Mutual Funds for Young Investors

Sarah Boesveld: Teacher keeps promise to mail thousands of former students letters written by their past selves

The Kosher Gourmet by Sharon Thompson Anyone can make a salad, you say. But can they make a great salad? (SECRETS, TESTED TECHNIQUES + 4 RECIPES, INCLUDING DRESSINGS)

April 2, 2014

Paul Greenberg: Death and joy in the spring

Dan Barry: Should South Carolina Jews be forced to maintain this chimney built by Germans serving the Nazis?

Mayra Bitsko: Save me! An alien took over my child's personality

Frank Clayton: Get happy: 20 scientifically proven happiness activities

Susan Scutti: It's Genetic! Obesity and the 'Carb Breakdown' Gene

Lecia Bushak: Why Hand Sanitizer May Actually Harm Your Health

Stacy Rapacon: Great Funds You Can Own for $500 or Less

Cameron Huddleston: 7 Ways to Save on Home Decor

The Kosher Gourmet by Steve Petusevsky Exploring ingredients as edible-stuffed containers (TWO RECIPES + TIPS & TECHINQUES)

Jewish World Review

The end of diseases may no longer be science fiction

By Mark Johnson


DNA molecule from Bigstock




New cell technique could lead to repairs in damaged DNA


JewishWorldReview.com |

LILWAUKEE — (MCT) Researchers working with University of Wisconsin stem cell scientist James Thomson and Northwestern University have developed a new way to repair damaged DNA, raising the possibility that doctors may one day be able to fix mistakes in our genetic code that cause a host of illnesses.

Reporting in the journal Proceedings of the National Academy of Sciences, researchers described using small RNA molecules to ferry a protein to a specific gene in a human cell. The protein, called Cas9, is found in the bacterium Neisseria meningitidis and has the ability to cut off sections of DNA.

By using this technique, scientists could conceivably remove a section of a gene that contains a harmful mistake known as a mutation. They could repair the gene or inactivate the gene altogether.

"With this system, there is the potential to repair any genetic defect, including those responsible for some forms of breast cancer, Parkinson's and other diseases," said Zhonggang Hou, one of two lead authors on the new paper and an assistant scientist on the regenerative biology team at the Morgridge Institute for Research in Madison.

Using RNA molecules to help edit the genome has become a hot area of biology over the past six months, said Aron Geurts, an associate professor in the department of physiology at the Medical College of Wisconsin. Geurts said the excitement surrounding this genome-editing work reminds him of the period in 2007 just after landmark papers by Thomson and Shinya Yamanaka of Japan showed it was possible to change a human skin cell into something extremely similar to an embryonic stem cell.



The new work could someday enhance medicine's emerging ability to read the human genome and connect diseases to specific mistakes in the script. This was the technique used in 2009 to find the mysterious disease threatening Nic Volker, the boy sequenced and treated successfully at Children's Hospital of Wisconsin and the Medical College of Wisconsin.

Genome-editing, if it ever becomes safe for use in the hospital, would allow doctors who have found a disease-causing problem in a person's genetic script to take the next step and correct the error. The idea would be similar to the way in which a writer edits a sentence to fix a grammatical mistake.

Although the technology is a long way from being ready for use in a hospital, it can be used in research. Scientists wishing to study a disease can now edit into a cell a genetic mistake, then study the disease as it unfolds.

"We've been very interested in this technique and we're excited that there's a new option out there for us," Geurts said.

The regenerative biology team at Morgridge is led by Thomson, the first scientist to isolate and grow human embryonic stem cells and a professor at University of Wisconsin's School of Medicine and Public Health. The experiments for the new study were conducted using both human embryonic stem cells and cells that have been reprogrammed to mimic them.

The new paper cautions that scientists did encounter a problem. In some cases, the wrong section of DNA was cut, usually a section very close to the actual target.


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"We definitely have research going on trying to resolve the off-target cleaving," Hou said. He acknowledged the new method will be more immediately useful in research. Use in human medicine is likely to be many years off.

Yan Zhang, the other lead author and a post-doctoral fellow at Northwestern, said that one possible solution to the targeting problem involves sending in two separate copies of the modified protein.

The scientists at the Morgridge Institute and Northwestern said their work is now focusing on improving the new method to create a better tool for genome engineering.

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