In this issue

Jonathan Tobin: Defending the Right to a Jewish State

Heather Hale: Compliment your kids without giving them big heads

Megan Shauri: 10 ways you are ruining your own happiness

Carolyn Bigda: 8 Best Dividend Stocks for 2015

Kiplinger's Personal Finance editors: 7 Things You Didn't Know About Paying Off Student Loans

Samantha Olson: The Crucial Mistake 55% Of Parents Are Making At Their Baby's Bedtime

Densie Well, Ph.D., R.D. Open your eyes to yellow vegetables

The Kosher Gourmet by Megan Gordon With its colorful cache of purples and oranges and reds, COLLARD GREEN SLAW is a marvelous mood booster --- not to mention just downright delish
April 18, 2014

Rabbi Yonason Goldson: Clarifying one of the greatest philosophical conundrums in theology

Caroline B. Glick: The disappearance of US will

Megan Wallgren: 10 things I've learned from my teenagers

Lizette Borreli: Green Tea Boosts Brain Power, May Help Treat Dementia

John Ericson: Trying hard to be 'positive' but never succeeding? Blame Your Brain

The Kosher Gourmet by Julie Rothman Almondy, flourless torta del re (Italian king's cake), has royal roots, is simple to make, . . . but devour it because it's simply delicious

April 14, 2014

Rabbi Dr Naftali Brawer: Passover frees us from the tyranny of time

Greg Crosby: Passing Over Religion

Eric Schulzke: First degree: How America really recovered from a murder epidemic

Georgia Lee: When love is not enough: Teaching your kids about the realities of adult relationships

Cameron Huddleston: Freebies for Your Lawn and Garden

Gordon Pape: How you can tell if your financial adviser is setting you up for potential ruin

Dana Dovey: Up to 500,000 people die each year from hepatitis C-related liver disease. New Treatment Has Over 90% Success Rate

Justin Caba: Eating Watermelon Can Help Control High Blood Pressure

The Kosher Gourmet by Joshua E. London and Lou Marmon Don't dare pass over these Pesach picks for Manischewitz!

April 11, 2014

Rabbi Hillel Goldberg: Silence is much more than golden

Caroline B. Glick: Forgetting freedom at Passover

Susan Swann: How to value a child for who he is, not just what he does

Cameron Huddleston: 7 Financial Tasks You Should Tackle Right Now

Sandra Block and Lisa Gerstner: How to Profit From Your Passion

Susan Scutti: A Simple Blood Test Might Soon Diagnose Cancer

Chris Weller: Have A Slow Metabolism? Let Science Speed It Up For You

The Kosher Gourmet by Diane Rossen Worthington Whitefish Terrine: A French take on gefilte fish

April 9, 2014

Jonathan Tobin: Why Did Kerry Lie About Israeli Blame?

Samuel G. Freedman: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Jessica Ivins: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Kim Giles: Asking for help is not weakness

Kathy Kristof and Barbara Hoch Marcus: 7 Great Growth Israeli Stocks

Matthew Mientka: How Beans, Peas, And Chickpeas Cleanse Bad Cholesterol and Lowers Risk of Heart Disease

Sabrina Bachai: 5 At-Home Treatments For Headaches

The Kosher Gourmet by Daniel Neman Have yourself a matzo ball: The secrets bubby never told you and recipes she could have never imagined

April 8, 2014

Lori Nawyn: At Your Wit's End and Back: Finding Peace

Susan B. Garland and Rachel L. Sheedy: Strategies Married Couples Can Use to Boost Benefits

David Muhlbaum: Smart Tax Deductions Non-Itemizers Can Claim

Jill Weisenberger, M.S., R.D.N., C.D.E : Before You Lose Your Mental Edge

Dana Dovey: Coffee Drinkers Rejoice! Your Cup Of Joe Can Prevent Death From Liver Disease

Chris Weller: Electric 'Thinking Cap' Puts Your Brain Power Into High Gear

The Kosher Gourmet by Marlene Parrish A gift of hazelnuts keeps giving --- for a variety of nutty recipes: Entree, side, soup, dessert

April 4, 2014

Rabbi David Gutterman: The Word for Nothing Means Everything

Charles Krauthammer: Kerry's folly, Chapter 3

Amy Peterson: A life of love: How to build lasting relationships with your children

John Ericson: Older Women: Save Your Heart, Prevent Stroke Don't Drink Diet

John Ericson: Why 50 million Americans will still have spring allergies after taking meds

Cameron Huddleston: Best and Worst Buys of April 2014

Stacy Rapacon: Great Mutual Funds for Young Investors

Sarah Boesveld: Teacher keeps promise to mail thousands of former students letters written by their past selves

The Kosher Gourmet by Sharon Thompson Anyone can make a salad, you say. But can they make a great salad? (SECRETS, TESTED TECHNIQUES + 4 RECIPES, INCLUDING DRESSINGS)

April 2, 2014

Paul Greenberg: Death and joy in the spring

Dan Barry: Should South Carolina Jews be forced to maintain this chimney built by Germans serving the Nazis?

Mayra Bitsko: Save me! An alien took over my child's personality

Frank Clayton: Get happy: 20 scientifically proven happiness activities

Susan Scutti: It's Genetic! Obesity and the 'Carb Breakdown' Gene

Lecia Bushak: Why Hand Sanitizer May Actually Harm Your Health

Stacy Rapacon: Great Funds You Can Own for $500 or Less

Cameron Huddleston: 7 Ways to Save on Home Decor

The Kosher Gourmet by Steve Petusevsky Exploring ingredients as edible-stuffed containers (TWO RECIPES + TIPS & TECHINQUES)

Jewish World Review

Scientists unveil new step in less-controversial stem-cell efforts

By Mark Johnson

When issues of morality confront the advancement of science, morality will always win. We just need to work hard to find solutions

http://www.JewishWorldReview.com | (MCT) By fusing mouse and human cells, scientists at Stanford have uncovered part of the mechanism involved in reprogramming skin cells back to their embryonic origin, and in doing so have shed light on the critical role played by a protein.

In a paper published in Nature, the researchers explained that they fused mouse embryonic stem cells to the cells in human connective tissue and achieved reprogramming far more rapidly and efficiently than had been done previously.

The new work allows scientists to begin understanding the crucial "how" of a revolution in cell biology launched in 2006 when Japanese scientist Shinya Yamanaka reprogrammed mouse cells. That breakthrough, which raised the possibility of creating embryonic stem cells that would not set off an ethical debate, was extended a year later when human cells were reprogrammed by Yamanaka in Japan and James Thomson at the University of Wisconsin-Madison.

Yamanaka and Thomson induced ordinary skin cells to return to their embryonic origin by inserting different four-gene combinations into the cells.

"It's sort of a mystery. You put in four factors. You wait two to three weeks. And .1 percent of the cells are reprogrammed," explained Helen M. Blau, director of the Baxter Laboratory for Stem Cell Biology at Stanford University School of Medicine. "It's amazing that it works but there's something missing that we don't understand."

The small number of reprogrammed cells returns to the embryonic state and regain the ability to become any cell in the body, a power that scientists call pluripotency.

"This provides the first real insight into the mechanism of how these cells become pluripotent," Stephen Duncan, a stem cell scientist at the Medical College of Wisconsin, said of the Nature paper. "From a science perspective, it's a really nice piece of work."

Fusing cells from different species allowed scientists to identify which proteins were made by human cells and which by mouse cells and therefore to determine that the human cell was reprogrammed.

Moreover, the experiment pulled back the curtain on another aspect of reprogramming, a process called demethylation. To understand the process, imagine traffic lights in a city. Strands of DNA contain methylation marks, which prevent genes from being turned on. It is as if all of the traffic in a city had been halted by a perpetual red light. The red light keeps the cell frozen in one identity — a bit of blood, or skin, or nerve.

The Nature paper shows that once methylation marks have been established they can still be removed, allowing the red light to switch to green. A green light frees the cell to move toward pluripotency, to that embryonic state when anything is possible.

The Stanford scientists found that a protein called AID, or activation-induced cytidine deaminase, is involved in the process of demethylation. Previously the protein had been known mostly for its role in generating antibodies for the immune system.

"We found a whole new function for it," Blau said, describing the protein as "a critical component in DNA demethylation.

When the Stanford team fused the human and mouse cells, 70 percent switched on the crucial genes that confer the power of an embryonic stem cell. And it did not take weeks, as other methods have, but rather, days.

Blau called the method "a powerful system" for examining how the reprogramming of cells works.

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