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December 2, 2014

Jonathan Tobin: Defending the Right to a Jewish State

Heather Hale: Compliment your kids without giving them big heads

Megan Shauri: 10 ways you are ruining your own happiness

Carolyn Bigda: 8 Best Dividend Stocks for 2015

Kiplinger's Personal Finance editors: 7 Things You Didn't Know About Paying Off Student Loans

Samantha Olson: The Crucial Mistake 55% Of Parents Are Making At Their Baby's Bedtime

Densie Well, Ph.D., R.D. Open your eyes to yellow vegetables

The Kosher Gourmet by Megan Gordon With its colorful cache of purples and oranges and reds, COLLARD GREEN SLAW is a marvelous mood booster --- not to mention just downright delish
April 18, 2014

Rabbi Yonason Goldson: Clarifying one of the greatest philosophical conundrums in theology

Caroline B. Glick: The disappearance of US will

Megan Wallgren: 10 things I've learned from my teenagers

Lizette Borreli: Green Tea Boosts Brain Power, May Help Treat Dementia

John Ericson: Trying hard to be 'positive' but never succeeding? Blame Your Brain

The Kosher Gourmet by Julie Rothman Almondy, flourless torta del re (Italian king's cake), has royal roots, is simple to make, . . . but devour it because it's simply delicious

April 14, 2014

Rabbi Dr Naftali Brawer: Passover frees us from the tyranny of time

Greg Crosby: Passing Over Religion

Eric Schulzke: First degree: How America really recovered from a murder epidemic

Georgia Lee: When love is not enough: Teaching your kids about the realities of adult relationships

Cameron Huddleston: Freebies for Your Lawn and Garden

Gordon Pape: How you can tell if your financial adviser is setting you up for potential ruin

Dana Dovey: Up to 500,000 people die each year from hepatitis C-related liver disease. New Treatment Has Over 90% Success Rate

Justin Caba: Eating Watermelon Can Help Control High Blood Pressure

The Kosher Gourmet by Joshua E. London and Lou Marmon Don't dare pass over these Pesach picks for Manischewitz!

April 11, 2014

Rabbi Hillel Goldberg: Silence is much more than golden

Caroline B. Glick: Forgetting freedom at Passover

Susan Swann: How to value a child for who he is, not just what he does

Cameron Huddleston: 7 Financial Tasks You Should Tackle Right Now

Sandra Block and Lisa Gerstner: How to Profit From Your Passion

Susan Scutti: A Simple Blood Test Might Soon Diagnose Cancer

Chris Weller: Have A Slow Metabolism? Let Science Speed It Up For You

The Kosher Gourmet by Diane Rossen Worthington Whitefish Terrine: A French take on gefilte fish

April 9, 2014

Jonathan Tobin: Why Did Kerry Lie About Israeli Blame?

Samuel G. Freedman: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Jessica Ivins: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Kim Giles: Asking for help is not weakness

Kathy Kristof and Barbara Hoch Marcus: 7 Great Growth Israeli Stocks

Matthew Mientka: How Beans, Peas, And Chickpeas Cleanse Bad Cholesterol and Lowers Risk of Heart Disease

Sabrina Bachai: 5 At-Home Treatments For Headaches

The Kosher Gourmet by Daniel Neman Have yourself a matzo ball: The secrets bubby never told you and recipes she could have never imagined

April 8, 2014

Lori Nawyn: At Your Wit's End and Back: Finding Peace

Susan B. Garland and Rachel L. Sheedy: Strategies Married Couples Can Use to Boost Benefits

David Muhlbaum: Smart Tax Deductions Non-Itemizers Can Claim

Jill Weisenberger, M.S., R.D.N., C.D.E : Before You Lose Your Mental Edge

Dana Dovey: Coffee Drinkers Rejoice! Your Cup Of Joe Can Prevent Death From Liver Disease

Chris Weller: Electric 'Thinking Cap' Puts Your Brain Power Into High Gear

The Kosher Gourmet by Marlene Parrish A gift of hazelnuts keeps giving --- for a variety of nutty recipes: Entree, side, soup, dessert

April 4, 2014

Rabbi David Gutterman: The Word for Nothing Means Everything

Charles Krauthammer: Kerry's folly, Chapter 3

Amy Peterson: A life of love: How to build lasting relationships with your children

John Ericson: Older Women: Save Your Heart, Prevent Stroke Don't Drink Diet

John Ericson: Why 50 million Americans will still have spring allergies after taking meds

Cameron Huddleston: Best and Worst Buys of April 2014

Stacy Rapacon: Great Mutual Funds for Young Investors

Sarah Boesveld: Teacher keeps promise to mail thousands of former students letters written by their past selves

The Kosher Gourmet by Sharon Thompson Anyone can make a salad, you say. But can they make a great salad? (SECRETS, TESTED TECHNIQUES + 4 RECIPES, INCLUDING DRESSINGS)

April 2, 2014

Paul Greenberg: Death and joy in the spring

Dan Barry: Should South Carolina Jews be forced to maintain this chimney built by Germans serving the Nazis?

Mayra Bitsko: Save me! An alien took over my child's personality

Frank Clayton: Get happy: 20 scientifically proven happiness activities

Susan Scutti: It's Genetic! Obesity and the 'Carb Breakdown' Gene

Lecia Bushak: Why Hand Sanitizer May Actually Harm Your Health

Stacy Rapacon: Great Funds You Can Own for $500 or Less

Cameron Huddleston: 7 Ways to Save on Home Decor

The Kosher Gourmet by Steve Petusevsky Exploring ingredients as edible-stuffed containers (TWO RECIPES + TIPS & TECHINQUES)

Jewish World Review

Medication shortages: 'Truly a public health crisis'

By Marie McCullough


Angel Boligan, El Universal, Mexico City, Cagle Cartoons





JewishWorldReview.com |

PHILADELPHIA — (MCT) Rationing medical care is denounced as immoral in the United States, yet it goes on daily in hospitals, clinics, nursing homes, ambulances and pharmacies.

Since 2006, this country has had worsening shortages of sterile generic injectables — drugs given by shots or intravenously. Currently, more than 300 medicines crucial to treating cancer, infections, cardiac arrest, premature infants, pain and more are in short supply.

The reasons for this predicament are complex, and the fixes, elusive. The scope, however, is clear from surveys of medical and trade groups. The latest, a University of Pennsylvania poll of oncologists released last month, found 83 percent had dealt with shortages by delaying cancer treatments, omitting doses, using second-choice drugs or sending patients elsewhere.

"Oncologists are facing wrenching decisions about how to allocate lifesaving drugs," said cancer specialist Keerthi Gogineni, who led the Penn survey.

Why aren't patients and families up in arms?

They may not realize their care was compromised or complicated by a shortage unless their caregivers are unusually candid.

"Patients in an intensive care unit often don't know they've been impacted," said pharmacist Erin Fox, who tracks shortages as manager of the University of Utah's drug-information service. "And the hospitals don't want folks to talk about it. They don't want to admit, 'We had a patient who died because we didn't have this drug.' "

The secret human toll is rising. In the last three years, dozens of deaths due to contaminated drugs have been linked to producers and vendors who have capitalized on shortages. The Institute for Safe Medication Practices (ISMP) in Horsham received hundreds of reports of medication errors, near-disasters, and 15 deaths related to shortages when it surveyed 1,800 health-care practitioners in 2010.

"This is the worst I've ever seen in over 40 years as a pharmacist," said Michael Cohen, ISMP president, who contributes to The Inquirer's Checkup blog. "It's truly a public health crisis."



One group of patients has been acutely aware and outspoken about the crisis because it threatens their health every day.

These 30,000 Americans cannot eat by mouth, usually from digestive diseases. They must get all nourishment — from vitamins to fat — in a customized, sterile solution pumped into a heart vein.

Total parenteral nutrition, or TPN, is also vital temporarily for premature newborns and hospitalized patients who can't eat.

"We were very vocal in outlining for (government officials) what we think needs to be done," said Joan Bishop, director of the nonprofit Oley Foundation in Albany, N.Y., a TPN support network. "You can't just let people starve."

Among the group's stalwart activists is Bettemarie Bond, 42, of Levittown. She suffers from rare digestive and metabolic disorders and has been on TPN since 1990. A single bite of, say, pizza, would set off excruciating inflammation in her pancreas and gut.

In her teens, doctors told Bond to prepare to be an invalid. Instead, helped by her parents and TPN specialists, she graduated from college, bought a house, and became a pediatric occupational therapist. She works with autistic preschoolers and hides her infusion pumps in a snazzy backpack.

To do all this, Bond has to conserve energy; even taking a shower can exhaust her. The shortages add needless stress. Consider that severe selenium deficiency can cause heart damage, yet she has not had the trace element for almost a year. She has gone without IV multivitamins for months at a time. She also worries that her infusion pharmacist will run out of the only pain medicationshe can tolerate. "Without it, the pain would be unbearable," she said.

Still, she considers herself lucky. "Some friends have had it much worse," she said. "They've gotten lipids (fats) just once a week instead of daily. It's affected their health."

Though shortages occur in other developed countries, the U.S. is especially vulnerable, experts agree.

In a recent analysis, Food and Drug Administration officials cited a root problem: U.S. factories that make sterile injectables are few, aging and inadequate, and manufacturers have no economic incentives to upgrade. When equipment breaks or inspectors find problems, it's often easier to quit making the injectables — which have high production costs and low profit margins — and divert the capacity to more lucrative products.

Only seven companies now make virtually all sterile injectables in the U.S., their plants running round the clock. Six have received repeated FDA warnings about safety lapses.


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Experts cite other factors behind shortages, including hospital group purchasing contracts that drive down prices, hoarding, and low insurance reimbursements.

"In Britain, prices are more regulated," said Michael Link, a Stanford University pediatric oncologist. "The reimbursement rate for generics is higher, and on-patent drug reimbursement is lower."

The FDA cannot order firms to make drugs, but recent legislation and a presidential order gave the agency more muscle. Last year, it began requiring companies to give early warnings of permanent and temporary drug discontinuations.

The agency also allowed temporary importation of a key ovarian cancer chemotherapy, as it did the year before for a leukemia drug. But importation is not ideal. Many foreign factories do not meet FDA standards. And global transport of heavy glass vials adds to costs.

Last month, an industry group, the International Society for Pharmaceutical Engineering, released the first global survey of companies and others. The intent was to see if steps already taken by industry and regulators were working.

The answer was not so well.

Of 142 respondents with a shortage-prevention program, more than half said "the company was still unable to prevent a drug shortage."

At the Institute for Safe Medication Practices, Michael Cohen has been dedicated to reducing drug errors and costs while improving quality. His work was honored with a 2005 MacArthur Foundation "genius" grant.

Shortages have set him back.

Medication errors have risen because practitioners are substituting unfamiliar drugs, formulations and concentrations. Lethal overdoses of a narcotic painkiller, adrenalin and a blood thinner have occurred, ISMP's most recent survey in 2010 found.

Costs have soared and product quality has suffered with the emergence of a "gray market," Cohen said. Shady vendors buy injectable drugs, often from "compounding" pharmacies, then resell the drugs at big markups. Compounding pharmacies, which are largely unregulated, can legally make only custom-order prescriptions, but some have become de facto factories to fill the shortage gap.

Their record has been spotty. In 2012, 48 people died and over 700 were sickened by fungal meningitis linked to spinal injections of steroids made by the New England Compounding Center in Framingham, Mass.

A few months ago, Cohen and leaders from the FDA, industry and medicine met to come up with new ideas to ease shortages.

Their list included extending product expiration dates, tax incentives for backup makers of key drugs, and curbing monopolistic buying practices.

But such proposals could take years to realize, Cohen said. Meanwhile, shortages continue.

"Imagine you go to the grocery store and milk, cheese, and all other sources of calcium are gone," said Bishop of the Oley Foundation. "And the clerk says: 'We don't know when we'll get any in.' "

Patients have the most to lose from drug shortages — and the least control over the problem.

Still, experts say you can be proactive:

Be aware of drugs you may need that are in short supply, especially if you are planning surgery, are in cancer treatment, or have a chronic condition such as heart disease. The FDA, the University of Utah, and the American Society of Health-System Pharmacists keep online lists of drugs in short supply.

Ask questions of health care providers. You (or your advocate) should ask whether your doctor is substituting, reducing, postponing or modifying a treatment because of a shortage. You should also know whether if your drug has come from a "compounding" pharmacy and if so, why.

Push for change. Write to your elected officials. Join lobbying efforts by patient groups such as the Oley Foundation and the National Patient Advocate Foundation.

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© 2013, The Philadelphia Inquirer. Distributed by McClatchy-Tribune Information Services.